Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments
نویسندگان
چکیده
منابع مشابه
Levodopa-induced dyskinesias in Parkinson's disease: etiology, impact on quality of life, and treatments.
Levodopa is the most effective agent to alleviate motor dysfunction in Parkinson's disease but its long-term use is associated with the development of dyskinesias. Although the pathogenic processes behind the development of levodopa-induced dyskinesias are still being elucidated, it appears that chronic administration of this short-lived agent results in nonphysiologic pulsatile stimulation of ...
متن کاملSlow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease.
The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson's disease is not well understood. We have recorded local field potentials (LFP) from macroelectrodes implanted in the subthalamic nucleus (STN) of 14 patients with Parkinson's disease following surgical treatment with deep brain stimulation. Patients were studied in the 'Off' medication state and in the 'On' motor state afte...
متن کاملMotor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias.
Experimental models of Parkinson's disease have demonstrated abnormal synaptic plasticity in the corticostriatal system, possibly related to the development of levodopa-induced dyskinesias (LID). We tested the hypothesis that LID in Parkinson's disease is associated with aberrant plasticity in the human motor cortex (M1). We employed the paired associative stimulation (PAS) protocol, an experim...
متن کاملMetoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.
Metoclopramide is an antiemetic drug which occasionally produced acute dystonic reactions. Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting. In this study metoclopramide did not increase Parkinsonism or reduce levodopa-induced involuntary movements in patients with Parkinson's disease. Pimo...
متن کاملFuture Scenarios for Levodopa-Induced Dyskinesias in Parkinson’s Disease
1 IBFM, National Research Council, Catanzaro, Italy 2 Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Rome, Italy 3 Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, Division of Neurology, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada 4 Dipartimento di Medicina Clinica e Sper...
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ژورنال
عنوان ژورنال: Neuropsychiatric Disease and Treatment
سال: 2013
ISSN: 1176-6328
DOI: 10.2147/ndt.s36693